Neoxpert IAP - Newborn Screening 3 Analytes

This test measures the levels of thyroid-stimulating hormone (TSH), Glucose-6-Phosphate Dehydrogenase (G6PD), and 17-hydroxyprogesterone (17-OHP) in the bloodspot of a newborn as per Indian Academy of Pediatrics (IAP) recommendation.

• To screen newborn babies for metabolic disorders or inborn errors of metabolism

To avoid complications such as intellectual disability, developmental delays, seizure disorders, or even death of newborns through early detection and clinical intervention

Neoxpert IAP is recommended for all newborn babies between 48 hours and 5 days of age. The test is especially important if there is a family history of metabolic disorders or inborn errors of metabolism or if the baby shows symptoms like poor feeding, vomiting, lethargy, hypoglycemia, or seizures.

• Abnormal levels of thyroid-stimulating hormone (TSH) in newborn screening may indicate congenital hypothyroidism, a condition where the baby has low levels of thyroid hormone, which can lead to developmental problems if left untreated.
• Abnormal levels of Glucose-6-Phosphate Dehydrogenase (G6PD) in newborn screening may suggest G6PD deficiency, an inherited enzyme deficiency that can cause red blood cell breakdown under certain conditions, leading to anemia and other complications.
• Abnormal levels of 17-hydroxyprogesterone (17-OHP) in newborn screening may indicate congenital adrenal hyperplasia (CAH), a group of genetic disorders affecting the adrenal glands' hormone production, which can lead to hormonal imbalances and potentially life-threatening conditions if not managed appropriately.

During the test, a healthcare provider will prick the baby’s heel to get a few drops of blood on a special filter paper. The blood sample will be then sent for analysis at a laboratory. The test is virtually painless and does not require much blood.

No special preparation is required for the test. However, it is advisable to feed your baby before the test to prevent dehydration and reduce discomfort. Inform your doctor if your baby is on medication or supplements or if you have any specific requirements for your baby.

If the results of Neoxpert IAP are abnormal, additional tests might be recommended depending on the suspected metabolic disorder or inborn error of metabolism. These could include:

• Plasma amino acid analysis
• Urine organic acid analysis
• Genetic testing

Newborn metabolic screening or heel stick test

Congenital adrenal hyperplasia (CAH) encompasses a range of genetic disorders impacting the adrenal glands' hormone production, including cortisol, which plays a crucial role in the body's response to stress and illness.