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Anti GAD-65 Paraneoplastic Syndrome Serum in Chennai
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Blood
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Male, Female
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Within 24 Hours
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GAD 65 Antibody Test Overview
Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Patients with insulin-dependent diabetes mellitus (IDDM) often have antibodies to GAD65 and several other islet cell antigens.
The GAD65 antibody is a biomarker of autoimmune central nervous system (CNS) disorders and, more commonly, non-neurological autoimmune diseases, like Type 1 diabetes, autoimmune thyroid disease, and pernicious anemia.
Anti-GAD-65 paraneoplastic syndrome is a rare neurological disorder caused by the immune system attacking the body's nervous system, specifically the GAD-65 protein. The GAD-65 protein is an enzyme that is involved in the production of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps to regulate the communication between nerve cells in the brain and spinal cord.
In the case of anti-GAD-65 paraneoplastic syndrome, the immune system produces antibodies against the GAD-65 protein, leading to a reduction in GABA production and disrupting nerve cell communication.
The paraneoplastic aspect of this syndrome means that it is associated with certain types of cancer, typically small-cell lung cancer, breast cancer, or ovarian cancer. In some cases, anti-GAD-65 antibodies are produced as part of the body's immune response to the cancer, rather than as a direct result of the cancer itself.
Associated Tests:
Yo Antibody Neuronal antibody for Paraneoplastic syndromes Serum
Amphiphysin Antibody Neuronal Ag in Paraneoplastic Syndrome Serum
Hu Antibody Neuronal ag in Paraneoplastic syndromes Serum
Ri Antibody, Serum
PNMA2 (MA2/TA) Antibody Serum
Neuronal Antibody Profile
Neuronal Antibody Profile-3
Written by : Supriya Kulkarni, Lead-Content & Training
Anti GAD-65 Paraneoplastic Syndrome Serum Price in Chennai
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Anti GAD-65 Paraneoplastic Syndrome Serum with a clear pricing structure
The price of Anti GAD-65 Paraneoplastic Syndrome Serum in Chennai is ₹ 6,900
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
GAD-65 antibody is useful to diagnose Insulin dependent Diabetes mellitus (IDDM) and development of related endocrine disorders like Thyroiditis. It is also used to diagnose Stiff Man syndrome & automimmune encephalitis.
This test is performed for patients suspected of suffering from autoimmune diseases like Insulin Dependent Diabetes Mellitus, Stiff Man syndrome & autoimmune encephalitis.
Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Patients with insulin-dependent diabetes mellitus (IDDM) often have antibodies to GAD65 and several other islet cell antigens. Also High serum levels of antibodies to the synaptic enzyme glutamic acid decarboxylase (GAD-abs) is a very sensitive biomarker of stiff-person syndrome (SPS) and have also been described in subgroups of patients with limbic encephalitis (LE), cerebellar ataxia,epilepsy, and isolated cases of palatal tremor, as well as downbeat or periodic alternating nystagmus. Patients with GAD-abs must be screened for an underlying cancer if they have clinical presentations different from those typically associated with this autoimmunity or develop classic PNS.
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