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Mammatyper - Therapy
In recent years numerous life-saving treatment options have been developed for the therapy of breast cancer. Today there is a wide selection of treatments available to fight each individual breast cancer type. For a personalized treatment recommendation, different approaches are selected and combined based on a sound diagnosis.
Clinical parameters guide the oncologist in assessing the suitable intervention e.g.:
- Surgery
- Sentinel lymph node biopsy
- Radiation therapy
In order to optimize the outcome the treatment regimen is typically complemented by a systemic therapy like:
- Chemotherapy
- Anti-hormone therapy
- Targeted therapy
BCS (Breast Conserving Surgery) based on http://onkopedia-guidelines.info
| Subtype | Systemic Therapy | Benefits of MammaTyper® |
|---|---|---|
| Luminal A-like | Endocrine therapy | Based on accurate measurement MammaTyper® supports differentiation of low risk Luminal A-like from high risk Luminal B-like by precise and reproducible MKI67 determination |
| Luminal B-like (HER2 negative) | Endocrine therapy + Cytotoxics | Accurate determination of hormone receptor > endocrine responder or non –responder Precise differentiation of low risk Luminal A-like from high risk Luminal B-like by accurate and reproducible MKI67 determination by MammaTyper® |
| Luminal B-like (HER2 positive) | Endocrine therapy + Cytotoxics + Anti-HER2 | Accurate determination of hormone receptor expression by MammaTyper® > endocrine responder or non –responder Accurate determination of ERBB2 expression by MammaTyper® |
| HER2 positive (non-luminal) | Anti-HER2 | Accurate determination of ERBB2 expression by MammaTyper® |
| Triple negative (ductal) | Cytotoxics | Accurate determination of ERBB2, ESR1, PGR expression negativity by MammaTyper® |
Based on the identified molecular subtype the 13th St Gallen International Breast Cancer Conference (2013) Expert Panel has established clear recommendations for the choice of most effective systemic treatments.
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