Multiple Sclerosis Profile, Mini Test in Varanasi

Diagnosis of multiple sclerosis & intrathecal inflammation.

This test is performed for patients suspected of having inflammation in the central nervous system.

The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS. These tests include the cerebrospinal fluid (CSF) IgG index and CSF oligoclonal band (OCB) detection. Abnormal CSF IgG indexes and OCB patterns have been reported in 70% to 80% of MS patients.Oligoclonal Bands by Isoelectric focusing has Sensitivity 90% and Specificity -94%. IgG oligoclonal bands (OCBs) are Present in (CSF) of more than 95% MS patients They are Associated with increased levels of disease activity and disability , The conversion from a clinically isolated syndrome to early relapsing-remitting MS ,Greater brain atrophy , and increased cortical lesion load/intrathecal inflammation. CSF IgG alone Best marker of disease activity in MS patients.