Anti TPO Antibody Test

Testing for thyroid antibodies is used to determine whether a patient has autoimmune thyroid disease-related hypothyroidism or hyperthyroidism. An underactive thyroid gland leads to hypothyroidism, and a hyperactive thyroid gland leads to hyperthyroidism. Additional uses for thyroid antibody testing include the ones listed below -

1. To identify autoimmune diseases like Graves' disease or Hashimoto's thyroiditis.
2. Choosing the most effective line of action.
3. To test the likelihood that your mild hypothyroidism will worsen over time.
4. To assess the fetal risk in pregnant women with thyroid disease.
5. To calculate the probability of relapse during Graves' disease therapy.

The TPO antibody test measures the levels of thyroid peroxidase antibodies that are targeted against the enzyme thyroid peroxidase. 

TPO antibody test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

Normal levels: no thyroid antibodies were found. This means that symptoms of hypothyroidism are probably not caused by a decrease in TPO.
High values: suggestive of  Hashimoto thyroiditis; these antibodies can also be seen in Grave's disease.

• You could require this test if you experience thyroid-related symptoms and your doctor thinks Hashimoto's or Grave's disease is to blame.
• You might also need this test if results from previous thyroid tests indicate that your thyroid hormone levels are abnormally high or low. These tests include hormone assays for T3, T4, and TSH (thyroid-stimulating hormone).

To assist in identifying Hashimoto's thyroiditis, the TPO antibody test is used. If you experience any of the following symptoms, consider getting tested -

1. Fatigue.
2. Irregular menstrual periods.
3. Arid skin.
4. Broken nails.
5. Constipation.
6. Cold sensitivity.
7. Aches and pains in muscles.
8. Depression.
9. Mental haze.

TPO antibody blood test requires no specific preparation. However, consult your healthcare provider for any specific preparations.

The normal range of thyroid peroxidase antibodies is 9.0 IU/mL. All ages are included in the reference values.

Increased thyroid peroxidase antibody levels are frequently linked to thyroid issues, which are recognised to be a contributing factor in infertility.

Graves disease is a disorder of the immune system which leads to hyperthyroidism due to the excess production of thyroid hormones. This can cause bulging of the eyes and goitre (enlargement of the thyroid gland).

Hashimoto's thyroiditis is an autoimmune disease where the immune cells in the body mistakenly attack the cells in the thyroid gland that produce thyroid hormones. This eventually leads to hypothyroidism.

Thyroperoxidase (TPO) is a thyroid hormone-producing enzyme. In certain autoimmune conditions, antibodies against this enzyme are produced by the immune cells and are called TPO antibodies. These antibodies target and destroy the enzymes leading to hypothyroidism. 

Your doctor may also recommend additional thyroid tests, such as tests for,

• Thyroglobulin antibodies.
• Thyroid-stimulating hormone (TSH).
• Free T4 hormone.
• T3 hormone.

• Thyroid autoantibodies.
• Thyroid peroxidase antibody.
• TPO Test
• Anti-TPO antibodies
• Thyroperoxidase (TPO)
• Iodide peroxidase

The anti-TPO test, or thyroid peroxidase antibody test, is a blood test that measures the level of antibodies against thyroid peroxidase (TPO) in the blood, helping diagnose autoimmune thyroid diseases like Hashimoto's thyroiditis and Graves' disease.

The anti-TPO antibody test is crucial for diagnosing and managing autoimmune thyroid diseases, differentiating them from non-autoimmune conditions, predicting future thyroid disorder risks, and monitoring disease progression and treatment effectiveness.

The benefits of the anti-TPO test include accurate diagnosis of autoimmune thyroid diseases, differentiation from other thyroid conditions, monitoring disease progression and treatment effectiveness, and predicting future thyroid disorder risks, especially in pregnant women.

No, fasting or any special preparation is needed before the anti-TPO test. However, it's important to inform your healthcare provider about any medications you are taking.

A positive anti TPO test result indicates the presence of TPO antibodies in the blood, suggesting an autoimmune response against the thyroid gland. This can be a sign of Hashimoto's thyroiditis or Graves' disease but must be interpreted with other clinical findings and tests.

High anti-TPO antibody levels indicate an increased immune response against the thyroid gland, leading to inflammation and reduced thyroid function. This may result in symptoms of hypothyroidism or hyperthyroidism, depending on the underlying condition.

Symptoms associated with elevated anti-TPO antibody levels can include fatigue, weight changes, sensitivity to cold, dry skin and hair, constipation, and, in some cases, signs of hyperthyroidism such as a rapid heart rate, anxiety, tremors, and excessive sweating. 

High TPO levels with normal TSH can indicate an early stage of autoimmune thyroid disease, where the autoimmune process is present but has not yet significantly affected thyroid function. Further monitoring may be necessary to assess disease progression.

Yes, Metropolis Healthcare offers home sample collection service for the anti-TPO test. This convenient service allows trained phlebotomists to visit your home and collect your blood sample, ensuring a safe, comfortable, and hassle-free experience. 

The anti-TPO test reports are typically available after 6 hours, depending on when the sample was collected and processed. Once the results are ready, your healthcare provider will review the findings and discuss any recommended next steps if required.