PV Panel Test (Jak-2 V617F Reflex To Jak-2 Exon 12 Mutation)-Blood

PV Panel analyzes specific genetic mutaions in JAK2 V617F. If the initial Jak-2 V617F test is negative, a reflex test for Jak-2 Exon 12 Mutation is performed to further investigate the possibility of PV.

• To detect and confirm cases of Polycythemia Vera • To differentiate between different types of myeloproliferative neoplasms (MPN) • To provide crucial information for treatment planning and monitoring disease progression

Your doctor may recommend PV Panel if • you have symptoms such as increased blood cell production, enlarged spleen, or abnormal blood counts, • you have a family history of MPN or known genetic risk factors, or • you have already been diagnosed with MPN and need further characterisation of the subtype for proper management.

Abnormal results indicate the need for further evaluation and consultation with a haematologist or oncologist.

During the test, a small amount of blood (3–5 ml) will be drawn from a vein in your arm. The blood sample will then be sent to the laboratory for analysis.

• Inform your doctor about any medications you are taking, as certain drugs might affect the test results. Also, tell them if you have any specific requirements. • Follow any specific instructions provided by your doctor regarding fasting, if necessary.

Depending on your specific case, your doctor may recommend the following additional tests to further evaluate and monitor your condition: • Complete Blood Count (CBC) • Bone Marrow Biopsy • Additional genetic testing such as JAK2 V617F allele burden assessment

Polycythemia Vera Genetic Testing or Genetic Analysis for Polycythemia Vera

Polycythemia Vera is a rare blood disorder characterised by the overproduction of red blood cells. This condition leads to an increased risk of blood clots, bleeding, and other complications. It is caused by genetic mutations in the bone marrow cells responsible for blood cell production.