Multiple Sclerosis Profile Maxi

For comprehensive Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings.

It can be challenging to diagnose MS. It cannot be diagnosed by a single test. Instead, to rule out some other disorders with comparable symptoms, a diagnosis often necessitates a number of tests.

If your doctor suspects you may have MS after performing a physical examination, they will probably prescribe a number of various tests.

If your physician suspects inflammation in your central nervous system, they will order a CSF oligoclonal banding. If there is a presence of oligoclonal bands of protein, multiple sclerosis is sometimes suspected as the cause.

This test assesses CSF Albumin, Serum Albumin, CSF Immunoglobulin G, Serum Immunoglobulin G, Oligoclonal Band, CSF Index and MAG Antibody.

The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS. These tests include the cerebrospinal fluid (CSF) IgG index and CSF oligoclonal band (OCB) detection. Abnormal CSF IgG indexes and OCB patterns have been reported in 70% to 80% of MS patients. They are Associated withIncreased levels of disease activity and disability, conversion from a clinically isolated syndrome to early relapsing-remitting MS ,Greater brain atrophy , and increased cortical lesion load/intrathecal inflammation.CSF IgG alone Best marker of disease activity in MS patients. Increased MAG antibodies :Predicts Progression to MS , relapsing remitting multiple sclerosis (RRMS).

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If you experience any of the following symptoms, consult a doctor -

• Numbness or weariness in one or more limbs. This typically impacts only one side of the body at a time.
• Certain neck motions, particularly tilting the neck forward, may give the sensation of an electric shock (Lhermitte sign).
• Improper coordination.
• An incapacity to move.
• Blindness, that is either partial or total. It is typically accompanied by pain.
• Vertigo.
• Gastrointestinal, urinary, and sexual function problems
• Fatigue.
• Speech that is shaky.
• Cognitive challenges.

If you encounter any of the symptoms listed above for an unidentified reason, consult a doctor.

For this test, both a blood test and a CSF sample are necessary. An elastic band used as a tourniquet is tightly placed around the upper arm to get a blood sample. The patient is then asked to make a fist. This facilitates the blood filling of the veins. The skin is cleansed prior to the needle insertion. The blood sample is collected using a vacutainer. Your doctor will have to take CSF samples.

Not necessarily. But you must share your medical history with your doctor before taking any of the tests.

CSF is used to diagnose MS (oligoclonal bands). This is done by qualitatively detecting increased intrathecal IgG production. One of the MS diagnostic requirements is the presence of two or more distinct CSF oligoclonal bands.

Multiple sclerosis, inflammatory neuropathy, and motor neuron diseases are all related to the myelin-associated glycoprotein antibody (MAG) presence.

Relapsing-remitting illness is present in most MS patients. They move through phases. Here they either experience the onset of new symptoms or relapse. These often last weeks or days to develop. There may be months or even years of peaceful sickness remission following these relapses.

Along with Multiple Sclerosis Profile Maxi, your doctor may recommend -

• Evoked potential tests.
• MRI.
• Spinal Tap.

Blood Tests.

CSF Albumin

Serum Albumin

CSF IgG

Serum IgG

Oligoclonal Band

CSF Index

MAG Antibody

Myelin-associated glycoprotein (MAG) Antibody

Detection of MAG antibodies is associated with demyelinating sensorimotor neuropathies associated with multiple sclerosis, inflammatory neuropathies, and motor neuron diseases.

The CSF index is the CSF IgG to CSF albumin ratio compared to the serum IgG to serum albumin ratio. The CSF index is, therefore, an indicator of the relative amount of CSF IgG compared to serum. Any increase in the index is a reflection of IgG production in the CNS. The index is independent of the activity of the demyelinating process.