MPO by EIA, p-ANCA Serum Test

The MPO by EIA, p-ANCA serum test is used to measures the autoantibodies related to MPO (MPO antineutrophil cytoplasmic antibodies, i.e, ANCA).

MPO (myeloperoxidase) by EIA (enzyme immunoassay) p-ANCA (perinuclear anti-neutrophil cytoplasmic antibody) serum test is performed to aid in the diagnosis and management of certain autoimmune diseases and vasculitis.

Here are some reasons why this test may be done:

1. To diagnose autoimmune diseases: It is used to help diagnose certain autoimmune diseases, such as microscopic polyangiitis (MPA), Wegener's granulomatosis, and Churg-Strauss syndrome.
2. To differentiate between different types of vasculitis: Vasculitis is a condition that causes inflammation and damage to blood vessels. The test can help differentiate between different types of vasculitis, such as MPA and granulomatosis with polyangiitis (GPA), which have different treatment approaches.
3. To monitor disease activity: These tests can be used to monitor disease activity and response to treatment in patients with autoimmune diseases and vasculitis.
4. To guide treatment decisions: The results of the test can help guide treatment decisions, such as determining the need for immunosuppressive therapy.
5. To detect relapse: The test may be used to detect relapse of disease in patients who have previously been diagnosed with an autoimmune disease or vasculitis.
6. To rule out other conditions: The test can help rule out other conditions that may have similar symptoms, such as infections or malignancies.
7. To assess disease severity: The results of the test can provide information on the severity of disease, which can be useful in determining prognosis and treatment options.

The MPO by EIA and p-ANCA serum test is typically ordered by a healthcare provider if a patient is experiencing symptoms such as:

• Joint pain and stiffness
• Fatigue and weakness
• Skin rash or sores
• Shortness of breath
• Chest pain
• Blood in urine
• High blood pressure

These symptoms can be indicative of several autoimmune diseases, such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). The MPO by EIA and p-ANCA serum test can help differentiate between these diseases and determine the best course of treatment.

The test involves drawing a small amount of blood from a vein in your arm. A healthcare professional will clean the area with an antiseptic, wrap an elastic band around your upper arm to make the veins more visible, and insert a needle into a vein to collect the blood sample. You may feel a brief prick or stinging sensation when the needle is inserted, but the procedure is generally painless.

No special preparation is required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status.

MPO by EIA and p-ANCA serum tests are often ordered together to help diagnose certain autoimmune diseases, such as vasculitis. However, additional laboratory tests may also be ordered depending on the suspected underlying condition or to further evaluate the results of the test:

1. Complete blood count (CBC): An abnormal CBC may indicate an underlying condition that could be causing the symptoms.
2. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP): They are often elevated in autoimmune diseases, including vasculitis.
3. Antinuclear antibody (ANA) test: ANA is often elevated in autoimmune diseases.
4. Rheumatoid factor (RF) test: This test detects antibodies that are present in rheumatoid arthritis, another autoimmune disease that can cause joint pain and inflammation.
5. Complement levels: In autoimmune diseases, complement levels can be low or high, depending on the specific condition.
6. Urinalysis: This test can detect protein or blood in the urine, which may be a sign of kidney damage or inflammation, which can occur in certain types of vasculitis.

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