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Mpl W515/S505 Mutation Analysis Test, Blood
50+ booked in last 3 days
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
NABL & CAP Accredited Labs
Accurate & Quality Test Reports
Trusted by Leading Doctors & Hospitals
Overview
The "MPL W515/S505 Mutation Analysis, Blood" test is used to detect mutations in the MPL gene, specifically in Codon W515 and Codon S505. Its clinical utility lies in suspected cases of essential thrombocythemia (ET) and primary myelofibrosis (PMF) where the presence of the Jak2 V617F mutation is negative. Essential thrombocythemia and primary myelofibrosis are myeloproliferative neoplasms characterized by abnormal blood cell production. The Jak2 V617F mutation is commonly associated with these conditions, but in some cases, it may not be present, leading to diagnostic uncertainty. In such situations, testing for MPL mutations becomes crucial, as detecting mutations in Codon W515 and Codon S505 can confirm the diagnosis of ET or PMF. Identifying these MPL mutations provides valuable diagnostic information, enabling accurate classification and management of these hematological disorders.
Mpl W515/S505 Mutation Analysis Test, Blood Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Mpl W515/S505 Mutation Analysis Test, Blood with a clear pricing structure.
The Mpl W515/S505 Mutation Analysis Test, Blood Price in Mumbai is ₹ 6,460 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
MPL W515/S505 Mutation Analysis analyzes specific mutations in the MPL gene, specifically in codon W515 and codon S505.
• To confirm the diagnosis of ET and PMF when other tests, like Jak2 V617F mutation analysis, are negative • To distinguish these blood disorders from other conditions with similar symptoms
• MPL W515/S505 Mutation Analysis is recommended in suspected cases of ET or PMF where the Jak2 V617F mutation has been ruled out. • Patients who have symptoms such as unexplained blood clots, enlarged spleen, or abnormal blood counts may require this test for proper diagnosis and treatment planning.
If the MPL W515/S505 Mutation Analysis shows the presence of mutations in the MPL gene, it suggests a higher likelihood of ET or PMF.
During the test, a healthcare professional will draw a blood sample of 3–5 ml from you. They will send the sample to a laboratory for testing.
• Inform your doctor about any medications you are taking as certain drugs may interfere with the test results. Also, tell them if you have any specific requirements. • Follow any instructions provided by your doctor regarding fasting or specific dietary restrictions, if any.
Other tests that may be ordered alongside MPL W515/S505 Mutation Analysis include Jak2 V617F mutation analysis, CALR mutation analysis, and bone marrow biopsy. These tests help in further evaluating and confirming the diagnosis of ET and PMF.
MPL Codon W515/S505 Mutation Analysis
ET and PMF are two types of blood disorders characterised by abnormal production of blood cells in the bone marrow. ET results in an increased number of platelets, while PMF leads to scarring of the bone marrow, affecting blood cell production, and organ function.
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Why Metropolis?
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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