Lupus Anticoagulants LAC Profile Test

The Lupus Anticoagulants (LAC) Profile measures the presence of lupus anticoagulant antibodies in the blood.

The Lupus Anticoagulants (LAC) Profile is done for several reasons, such as: • To diagnose conditions associated with abnormal blood clotting • To monitor the effectiveness of treatment for these conditions • To assess the risk of developing blood clots • To evaluate unexplained recurrent miscarriages or fetal loss • To investigate prolonged APTT (Activated Partial Thromboplastin Time)

Your doctor may recommend the Lupus Anticoagulants (LAC) Profile if you have • An unexplained history of recurrent miscarriages or fetal loss. • Symptoms suggestive of abnormal blood clotting, such as deep vein thrombosis or pulmonary embolism. • A family history of abnormal blood clotting disorders. • A prolonged APTT test result. • Autoimmune diseases like systemic lupus erythematosus (SLE).

Abnormal results may indicate the presence of lupus anticoagulant antibodies and an increased risk of blood clotting disorders.

During the Lupus Anticoagulants (LAC) Profile: • A blood sample will be collected from a vein in your arm. • The sample will be sent to the laboratory for testing.

Before the Lupus Anticoagulants (LAC) Profile: • Inform your doctor about any medications you are taking, as certain drugs can interfere with test results. • Follow any instructions given by your doctor regarding fasting or dietary restrictions. • Wear loose-fitting clothing that allows easy access to your arm for sample collection. Please reach out to your healthcare provider for any specific requirements.

Other tests that may be ordered alongside the Lupus Anticoagulants (LAC) Profile include: • APTT (Activated Partial Thromboplastin Time): Measures factors involved in blood clotting • PT/INR (Prothrombin Time/International Normalised Ratio): Measures the time it takes for blood to clot • Thrombophilia Panel: Evaluates genetic and acquired risk factors for abnormal blood clotting • Mixing Studies: Used to determine the cause of prolonged clotting times

Lupus Anticoagulant Screen and Confirmation test

Antiphospholipid syndrome is an autoimmune disorder characterised by the presence of specific antibodies that increase the risk of blood clot formation. It can lead to complications such as deep vein thrombosis, pulmonary embolism, stroke, and recurrent miscarriages. The Lupus Anticoagulants (LAC) Profile is used to diagnose this condition as well.

The lupus anticoagulant test is a series of blood tests designed to detect the presence of lupus anticoagulants, which are autoantibodies that increase the risk of blood clots. These tests are part of diagnosing antiphospholipid syndrome (APS) and other thrombotic disorders.

The lupus anticoagulant test detects the presence of lupus anticoagulants, which are autoantibodies that target phospholipids and proteins associated with them, leading to an increased risk of blood clots.

The test reports indicate whether lupus anticoagulants are present in the blood. Positive results on two or more occasions at least 12 weeks apart can confirm the diagnosis of antiphospholipid syndrome (APS).

If the test reports are positive, it means that lupus anticoagulants are present, increasing the risk of blood clots and other complications associated with APS. Treatment may include blood-thinning medications, steroids, or plasma exchange, depending on the individual's condition and medical history.

The benefits include early diagnosis of antiphospholipid syndrome and other thrombotic disorders, which allows for timely treatment to prevent future blood clots and complications such as recurrent miscarriages or organ failures.

The risks associated with the test are minimal and include a brief sting from the needle, potential soreness at the injection site, and a slight risk of infection or bleeding, similar to any blood test.

The DRVVT test is highly sensitive for detecting lupus anticoagulants and uses venom from the Russell viper to activate the coagulation pathway, making it distinct from other tests like PTT, which may not specifically detect lupus anticoagulants.

The primary disease diagnosed with this test is antiphospholipid syndrome (APS), an autoimmune disorder characterized by excessive blood clot formation and other complications such as recurrent miscarriages and organ failures.

Yes, certain medications can affect the results of the lupus anticoagulant test. For example, warfarin (a vitamin K antagonist) and specific antibodies to factor VIII can interfere with the interpretation of results. Additionally, some medications can induce the production of lupus anticoagulants.

No, fasting is not typically required before taking the lupus anticoagulant test. However, your healthcare provider may provide specific instructions based on other tests you might be undergoing concurrently.

Several factors can affect the test results, including the presence of other coagulation disorders, certain medications, and transient production of lupus anticoagulants due to infections or other conditions.

The test reports are usually available after 6 hours, depending on the laboratory and the specific tests included in the lupus anticoagulant normal range profile. Your healthcare provider will inform you about the expected turnaround time for the results.