Leukemia panel by FISH - CLL

The Leukemia CLL panel studies the bone marrow sample for CEP12,17p (p53),13q ATM,6q, 11q gene rearrangement by FISH analysis.

Leukemia may often be asymptomatic in the early stages. People with following clinical signs should however, undergo the test:

• Pale looking skin 
• Fatigue, easy tiredness
• Unexplained weight loss
• Frequent infections, fever
• Bone or joint pain and tenderness
• Easy bleeding or bruising with red spots or purplish discoloration.

• In case of abnormalities detected in the routine blood examination (CBC) along with other investigations, the Leukemia FISH panel may be useful for further diagnosis.
• To find out the type of leukemia or lymphoma
• This panel helps in establishing the prognosis of chronic lymphocytic leukemia (CLL) patients into risk groups.
• This panel aids proper diagnosis, helps in choosing the right treatment line and monitoring of the patient.
• The panel helps monitor response to therapy with specific probes (CHR FISHI) or progression of disease.
• FISH cytogenetic testing is indicated as an initial evaluation for patients suspected to have Leukemia and then, if positive for a specific marker, for monitoring disease status

This test requires bone marrow sample along with whole blood smear. A small incision is made on the skin, and a hollow needle is inserted from the bone up to the bone marrow to collect the bone marrow sample. The skin is disinfected before needle insertion and the sample is collected in vacutainer.

Medical history / Heamato-pathological reports is required.

Normal Result indicates no evidence of translocation or rearrangements involving the chromosomal patterns.

Positive results indicate that abnormality has been identified.

Unfavourable outcomes are deletion 17p, followed by deletion 11q trisomy 12, deletion 6q.

Favourable outcome is deletion 13q Based on the results, the prognosis can be determined.

• Leukemia Test
• Blood Smear test