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JAK2 V617 Mutation Test, With Reflex To Jak2 Ex- 12, CALR Ex-9 Mutation And MPL W515, S505 Mutation, Bone Marrow
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Sample Type
Blood
Recommended for
Male, Female
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Within 24 Hours
Blood test at Home
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Overview
JAK2 V617 Mutation, with reflex to Jak2 Ex-12, CALR Ex-9 Mutation, and MPL W515, S505 Mutation, performed on bone marrow samples, serves as a molecular diagnostic test for suspected cases of myeloproliferative neoplasms (MPNs) including Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF). The test initially detects the JAK2 V617F mutation, which is a common molecular marker in MPNs. If the JAK2 V617F mutation is detected, further mutation analysis for Jak2 Ex-12, MPL W515/S505, and CALR Ex-9 is not indicated, as the presence of the JAK2 V617F mutation confirms the diagnosis of an MPN. This comprehensive molecular testing approach provides valuable information for the diagnosis and classification of MPNs, aiding in the management and treatment decision-making for patients with suspected PV, ET, or PMF.
JAK2 V617 Mutation Test, With Reflex To Jak2 Ex- 12, CALR Ex-9 Mutation And MPL W515, S505 Mutation, Bone Marrow Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the JAK2 V617 Mutation Test, With Reflex To Jak2 Ex- 12, CALR Ex-9 Mutation And MPL W515, S505 Mutation, Bone Marrow with a clear pricing structure.
The JAK2 V617 Mutation Test, With Reflex To Jak2 Ex- 12, CALR Ex-9 Mutation And MPL W515, S505 Mutation, Bone Marrow Price in Mumbai is ₹ 13,145 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
The JAK2 V617 Mutation Reflex Test initially detects the JAK2 V617F mutation. If JAK2 V617F mutation is not detected, further mutation analysis for Jak2 Ex-12, MPL W515/S505, and CALR Ex-9 is indicated.
• To confirm the diagnosis of myeloproliferative neoplasms (MPN) in suspected cases • To differentiate MPN from other blood disorders. • To guide treatment decisions and monitor the response to therapy in • MPN patients
This test is recommended for individuals who have • symptoms suggestive of MPN such as unexplained fatigue, night sweats, or an enlarged spleen, • abnormal blood cell counts or other laboratory findings indicating a potential blood disorder, or • a family history of MPN or genetic risk factors for MPN.
If the JAK2 V617 Mutation Reflex Test shows an abnormal result, it may indicate the presence of a mutation associated with MPN.
During the test, a bone marrow sample is collected using a needle. The sample is sent to the laboratory for analysis using real-time PCR, Sanger sequencing and PCR fragment analysis methods.
• A clinical diagnosis and test prescription from your doctor are mandatory. • Avoid any dietary restrictions unless advised by your doctor. • Inform your doctor about any medications or supplements you are taking that may interfere with the test results. Also, tell them if you have any specific requirements.
• MPL W515/S505 Mutation Analysis: This test checks for mutations in the MPL gene associated with myeloproliferative neoplasms. • CALR Ex-9 Mutation Analysis: This test detects mutations in the CALR gene, which may also be involved in myeloproliferative neoplasms.
JAK2 Ex-12, MPL W515/S505 or CALR Ex-9 Mutation Analysis
Myeloproliferative neoplasms are a group of blood disorders characterised by the overproduction of blood cells in the bone marrow. MPN includes conditions such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).
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Why Metropolis?
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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