IGRAS/ Interferon Gamma Release Assay

This test measures the levels of interferon gamma in your blood. It helps determine if you have been infected with tuberculosis (TB) bacteria by assessing your immune response. Elevated levels of interferon gamma may indicate a TB infection.

• To diagnose tuberculosis infections
• To monitor treatment effectiveness for tuberculosis
• To distinguish between latent tuberculosis infection and active disease
• To assess the risk of developing active tuberculosis in individuals exposed to the disease

This test is recommended when:

• You have symptoms suggestive of tuberculosis, like persistent cough, fever, weight loss, or night sweats
• You have been in close contact with someone diagnosed with tuberculosis
• You have a positive tuberculin skin test (Mantoux test) but a chest X-ray isn't conclusive
• You have an impaired immune system due to conditions such as HIV/AIDS

Normal values for Interferon-gamma vary depending on the laboratory and testing method used. Abnormal results may suggest a tuberculosis infection or exposure. However, further evaluation is needed, including a chest X-ray and clinical assessment, to confirm the diagnosis and determine the appropriate treatment.

During this test:

• A small sample of your blood will be drawn using a needle
• The blood sample will be sent to the laboratory for testing
• The laboratory will use a method called ELISA to measure the levels of Interferon-gamma in your blood

To prepare for this test:

• Inform your doctor about any medications you are taking, as certain drugs may affect the test results
• Follow any fasting or dietary restrictions, if advised by your doctor
• Wear comfortable clothing that allows easy access to your arm for blood collection

• Chest X-ray: This imaging test helps determine the presence and extent of tuberculosis in your lungs.
• Sputum Culture: This test helps identify the specific bacteria causing tuberculosis in your respiratory system.
• GeneXpert MTB/RIF Test: This molecular test detects the genetic material of tuberculosis bacteria and assesses antibiotic resistance.

Interferon-gamma Release Assay or IGRA

Tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis. It primarily affects the lungs but can also involve other organs. TB is spread through the air when an infected person coughs or sneezes. Early detection and treatment are important to prevent its spread.