Breast IHC Panel-ER, PR, HER2/neu (c-erb-B2), Ki-67

This panel measures the expression levels of specific protein markers, including ER, PR, c-erb-B2 (HER2/neu), and Ki 67 in breast tissue samples. The panel guides treatment options and assess tumor characteristics.

This test is performed for several reasons, including:

• To diagnose breast cancer and determine its subtype
• To assess the hormone receptor status of the tumor
• To evaluate HER2/neu protein expression
• To determine the proliferative index of breast cells
• To guide treatment decisions and monitor response to therapy

This test is recommended for individuals who:

• Have been diagnosed with breast abnormalities or suspected breast cancer
• Require further evaluation of their hormone receptor status or HER2/neu expression
• Need prognostic information about their breast condition
• Are undergoing treatment for breast cancer and require monitoring of treatment response

Abnormal results of this test may indicate various conditions, including:

• Positive hormone receptor expression, suggesting a subtype of breast cancer that may respond to hormone therapy
• Overexpression of HER2/neu, indicating a higher-risk breast cancer that may require targeted therapy
• High Ki 67 proliferation index, indicating an aggressive tumor with a higher likelihood of recurrence

Discuss your test results with your doctor for further evaluation and appropriate management.

• A small sample of breast tissue is collected through a biopsy or surgery in a hospital or clinical setup.
• The tissue sample is processed and stained.
• The stained tissue is examined under a microscope to assess the expression levels of ER, PR, c-erb-B2, and Ki 67.

• Provide the original histopathology report and relevant clinical and radiological details.
• Follow any additional instructions provided by your doctor and the laboratory.

• Molecular testing for genetic mutations in breast cancer genes (e.g., BRCA1/BRCA2)
• Imaging tests such as mammography, ultrasound, or MRI for further evaluation of breast abnormalities
• Additional pathology tests, such as hormone receptor testing or HER2/neu gene amplification testing

Immunohistochemistry Panel for Breast Tissue Evaluation

Breast cancer is a type of cancer that develops from cells in the breast. It is the most common cancer affecting women worldwide, though it can also occur in men.