Breast IHC Panel-ER, PR, HER2/neu (c-erb-B2)

This test detects the presence of estrogen receptor (ER), progesterone receptor (PR), and c-erb-B2 proteins in breast tissue. These proteins are important for understanding the hormone status and aggressiveness of breast cancer.

• To determine the hormone receptor status of breast cancer (whether the cancer cells have receptors for estrogen or progesterone)
• To assess the aggressiveness of breast cancer
• To guide treatment decisions for breast cancer

This test is recommended in the following situations:

• Newly diagnosed breast cancer patients to determine hormone receptor status
• For patients with recurrent or metastatic breast cancer to reassess hormone receptor status
• As a follow-up test to monitor treatment response

Abnormal ER and PR levels indicate that hormone therapy may be beneficial in treating breast cancer. Abnormal c-erb-B2 levels may indicate a more aggressive form of breast cancer and the need for targeted therapy. Abnormal results may guide treatment decisions and further diagnostic tests. It is important to discuss the results with your doctor.

• A small sample of breast tissue will be collected.
• The sample will be sent to the laboratory for analysis.
• The laboratory will use a method called immunohistochemistry (IHC) to detect and measure the levels of ER, PR, and c-erb-B2 proteins in the tissue sample.

• Follow any specific instructions provided by your doctor regarding fasting or medication use.
• Have any relevant medical reports or radiological images available for reference.

• HER2 gene amplification test: To determine if breast cancer has an overexpression of HER2 protein
• Ki-67: To assess the proliferation rate of breast cancer cells
• Genetic testing for BRCA1 and BRCA2 mutations: To identify inherited gene mutations that increase the risk of developing breast cancer

• Breast Hormone Receptor Test
• Estrogen receptor (ER) Test
• Progesterone receptor (PR) Test
• Her2/neu Test
• c-erb-B2 Test

Breast cancer is a type of cancer that forms in the cells of the breast. It can occur in both men and women, but it is more common in women. Breast cancer usually starts as a lump or mass in the breast tissue.