HLA Typing A, B, C, DR, DQ (Class I & Class II)

This test measures the specific HLA genes in your blood to determine your tissue type. It identifies the unique combination of antigens on the surface of your cells, which is important for matching donors and recipients in organ and tissue transplantation.

• To assess compatibility between potential organ donors and recipients
• To diagnose and monitor certain autoimmune diseases
• To understand the risk of developing certain genetic conditions
• To aid in paternity testing or forensic investigations involving DNA analysis

This test is recommended for individuals:

• Requiring an organ or tissue transplant
• Diagnosed with autoimmune diseases such as rheumatoid arthritis or celiac disease
• Suspected of having a genetic condition that involves HLA genes
• Involved in paternity disputes or legal investigations requiring DNA analysis

Abnormal results may indicate a higher risk of organ rejection in transplantation or suggest the presence of autoimmune diseases or genetic conditions. However, abnormal results do not definitively diagnose a specific condition. You should discuss your results with your doctor for further evaluation and interpretation.

• A blood sample will be collected from your arm using a needle.
• The sample will be sent to the laboratory for analysis.
• The test is painless, but you may feel a slight pinch when the needle is inserted.

Blood Collection:

• Collect blood 24 hours after dialysis to minimize interference from residual heparin.

Documentation:

• Use the specific HLA form designated for the test.
• Informed consent using the designated form is required.
• Patient's clinical history is needed.
• Include the clinician's number for identification.

HLA Test Requisition Form (TRF):

• Complete the TRF accurately and comprehensively.
• Provide detailed clinical history relevant to the test.
• Specify the relationship between patient and donor (if applicable).
• Include doctor-attested (signature & stamp) photographs of the recipient and donor (if applicable).

Other tests that may be ordered alongside HLA Typing A, B, C, DR, DQ include:

• Crossmatch Testing: To assess compatibility between organ donors and recipients before transplantation
• Autoantibody Testing: To detect specific antibodies associated with autoimmune diseases
• Genetic Testing: To confirm the presence of specific genetic mutations associated with certain conditions

HLA Typing, HLA Matching or Human Leukocyte Antigen Typing

Tissue typing refers to determining the compatibility between the donor's tissues and the recipient's immune system. It is crucial in organ and tissue transplantation to minimise the risk of rejection. Tissue typing helps identify the most suitable donors, ensuring better outcomes in transplantation procedures.