HLA Typing A, B (Class I) and DR loci (Class II)

HLA typing determines the specific human leukocyte antigen (HLA) alleles present in an individual's genetic makeup, specifically for Class I HLA-A and HLA-B loci, as well as Class II HLA-DR loci.

• To identify suitable organ and tissue donors for transplant patients
• To minimise the risk of graft rejection by matching HLAs between donors and recipients
• To diagnose certain autoimmune diseases where specific HLA types are associated
• To evaluate the risk of developing certain diseases or conditions related to specific HLA types

• Organ transplant recipients or potential donors
• Individuals with a family history of autoimmune diseases
• Patients suspected of having autoimmune disorders like rheumatoid arthritis or celiac disease
• People with certain genetic conditions that are associated with specific HLA types

An abnormal result in HLA typing may indicate an increased risk of graft rejection in transplantation or susceptibility to certain autoimmune diseases. It is important to discuss the results with your doctor who will interpret them in conjunction with your medical history and other diagnostic tests.

• A blood sample will be collected from your arm using a needle.
• The sample will be sent to the laboratory for testing.
• The laboratory will use a technique called Polymerase Chain Reaction (PCR) to analyse your DNA and determine specific HLA types.

• No fasting or special preparations are necessary for this test.
• Inform your doctor about any medications you are taking.
• Follow any specific instructions given by your doctor regarding dietary restrictions or medication management.

Other related tests that may be ordered alongside this test include:

• Cross-matching: This test helps determine compatibility between the donor's and recipient's immune systems.
• Donor-specific antibody testing: This test detects antibodies that may cause rejection in organ transplant recipients.

Human Leukocyte Antigen Typing A, B, and DR Loci Test

Human Leukocyte Antigen (HLA) Typing Class 1 & 2 Test

Organ transplantation is a surgical procedure where a healthy organ or tissue is removed from one person (donor) and transplanted into another person (recipient) with organ failure or disease. It is a life-saving treatment for many conditions.