Panel Reactive Antibody (PRA) Identification By Luminex (Class I)

The PRA Identification Test measures the presence of antibodies in a recipient's blood against specific human leukocyte antigens (HLA) Class I.

• To assess compatibility between a transplant recipient and a potential donor • To reduce the risk of rejection after organ transplantation • To guide treatment decisions for individuals requiring organ transplants • To evaluate the effectiveness of immunosuppressive therapy

This test is recommended for individuals who • are candidates for organ transplantation, such as kidney or liver transplant, • have had previous organ transplants and require ongoing monitoring, • require adjustments to immunosuppressive medication, or • are involved in living donor programs to ensure compatibility.

Abnormal results may indicate a higher risk of organ rejection or a lower chance of finding a compatible donor.

A blood sample will be collected from your arm. The sample will be sent to the laboratory for analysis.

• Inform your doctor about any medications or supplements you are taking. Also, tell them if you have any specific requirements. • Follow any additional instructions provided by your healthcare provider regarding discontinuation of immunosuppressive medication before the test.

Crossmatching: This test determines if a potential donor's organ is compatible with the recipient's immune system. HLA Typing: It identifies the specific HLA antigens present in an individual's blood to assess compatibility for transplantation.

HLA Class I PRA testing

Organ transplant rejection occurs when the recipient's immune system recognises the transplanted organ as foreign and attacks it. Rejection can lead to organ failure.