HLA (Lymphocyte) Cross Match - Total (T+B) Cells

The HLA (Lymphocyte) Cross Match evaluates the compatibility of T cells and B cells from the donor with antibodies present in the recipient's serum. It aims to identify potential immune responses against the transplanted organ or tissue.

• Transplant Compatibility: The test assesses the compatibility between donor and recipient to minimize the risk of immune-mediated graft rejection. • Preventing Complications: Identifying potential immune reactions early helps avoid post-transplant complications and optimize the success of the transplantation.

The HLA (Lymphocyte) Cross Match - Total (T+B) Cells is recommended for: • Patients undergoing solid organ or tissue transplantation (e.g., kidney, heart, liver, bone marrow). • Recipients with a history of prior sensitization to HLA antigens (e.g., previous transplants, blood transfusions).

A positive cross match indicates the presence of donor-specific antibodies that could lead to immune reactions against the transplanted organ or tissue. In such cases, the transplantation team may consider alternative strategies to minimize the risk of graft rejection.

The test involves mixing recipient serum with donor lymphocytes and observing whether antibodies in the recipient's serum react with the donor cells.

Patients may be advised to fast before the test or follow specific instructions provided by healthcare providers.

• HLA Typing: Prior HLA typing of both the donor and recipient helps identify potential mismatches that could trigger immune responses. • Cross Match Variants: Depending on the case, other cross match variants, such as B-cell cross match or T-cell cross match, may be considered.

• Total Lymphocyte Cross Match • Mixed Lymphocyte Cross Match