Gliadin-IgA Antibodies Deamidated (DGP) Serum Test in Govandi

Celiac disease (CD) is an immune-mediated enteropathy induced by dietary gluten. 
When a genetically predisposed individual consumes food containing gluten like  wheat, barley, rye, and other grains ,inflammation and damage of the small bowel mucosa occurs which leads to malabsorption , loss of bone density, miscarriage, infertility or even neurological diseases or certain cancers. Gliadin IGA test is a non invasive , quantitative determination of IgA antibodies against deamidated gliadin protein epitopes (DGP) in human serum or plasma.

Gliadin-IgA Antibodies Deamidated (DGP) Serum is an ELISA test used to measure the amount of IgA antibodies against deamidated gliadin peptide epitopes (DGP) in the serum. This test is used to diagnose celiac disease in patients who are negative for anti-tTG (Anti-Tissue-Transglutaminase IgG), especially children younger than 2 years old. Elevated Gliadin-IgA antibodies indicate celiac disease. The IgA antibodies make it possible to determine the level of disease activity and monitor adherence to a gluten-free diet.
 

What is Celiac Disease?

Celiac disease (CD) is an immune-mediated enteropathy induced by dietary gluten. It occurs when the body's immune system reacts to gluten, a protein found in rye, barley, and wheat. When an individual with celiac disease consumes gluten, their immune system responds by damaging the small intestine. Hence, the small intestine is unable to absorb nutrients, causing malnutrition and other health complications.

Written by: Dr Mukilarasi K R, M.D Pathology