Ganglioside IgM Antibody, serum

Test detects IgG antibodies against 7 gangliosides. The antibodies can help diagnose multifocal neuropathy, Gullian barre syndrome, Miller fisher syndrome & sensory neuropathy

Test is done for patients likely to suffering from autoimmune central nervous system disorders

Among the immune-mediated peripheral neuropathies, autoantibodies to gangliosides represent an important class of noncancer-associated autoimmune peripheral neuropathies including multifocal neuropathy, Gullian barre syndrome, Miller fisher syndrome & sensory neuropathy

• To diagnose autoimmune neurological disorders such as Guillain-Barré syndrome, Miller Fisher syndrome, and chronic inflammatory demyelinating polyneuropathy (CIDP).
• To monitor the progression of these neurological disorders and assess the effectiveness of treatment.
• To evaluate the risk of developing an autoimmune neurological disorder in individuals who have a family history of the disease or have been exposed to certain environmental factors.
• To rule out other conditions that may have similar symptoms to autoimmune neurological disorders, such as infections or metabolic disorders.
• To assist in the differential diagnosis of neurological disorders that have similar clinical presentations.
• To confirm the diagnosis of a suspected autoimmune neurological disorder that is based on clinical symptoms and other laboratory findings

The Ganglioside IgM Antibody Serum test measures the levels of IgM antibodies that are specific to gangliosides.

When ganglioside IgM antibodies are present in the serum, it is often an indication of an autoimmune disorder affecting the nervous system

The test involves drawing a small amount of blood from a vein in your arm. A healthcare professional will clean the area with an antiseptic, wrap an elastic band around your upper arm to make the veins more visible, and insert a needle into a vein to collect the blood sample. You may feel a brief prick or stinging sensation when the needle is inserted, but the procedure is generally painless.

No special preparation is required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status.

A Ganglioside IgM Antibody Serum test may be recommended if a person has symptoms that suggest an autoimmune neurological disorder such as Guillain-Barré syndrome, Miller Fisher syndrome, or chronic inflammatory demyelinating polyneuropathy (CIDP). Some of the symptoms that may warrant this test include:

• Progressive muscle weakness and atrophy
• Sensory disturbances such as numbness, tingling, or pain
• Difficulty with balance and coordination
• Impaired reflexes
• Vision changes, including double vision or difficulty moving the eyes
• Facial weakness or paralysis
• Difficulty speaking or swallowing
• Respiratory muscle weakness

Other individuals who may be recommended for a Ganglioside IgM Antibody Serum test include those who have a family history of autoimmune neurological disorders or have been exposed to certain environmental factors that increase the risk of developing these disorders.

Several other tests in addition to the Ganglioside IgG Antibody Serum test may be ordered to help confirm or rule out a diagnosis

• Cerebrospinal fluid (CSF) analysis: This test involves collecting a sample of the fluid that surrounds the brain and spinal cord and can help detect any inflammation or infections that may be affecting the nervous system.
• Autoantibody panel: This test measures the presence of various antibodies that may be associated with autoimmune conditions and can help identify other potential causes of the symptoms.

Anti-Ganglioside Antibody Test

Anti-Ganglioside Antibody Panel

GM1, GD1a, GD1b, GQ1b, GT1a