Free Androgen Index (FAI) Test

FAI is used to identify excessive androgen activity and thus useful in the evaluation of mild disorders of androgen metabolism. It is also used to diagnose other hormonal disorders.

The test measures the ratio of testosterone to SHBG in the blood.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

A high free androgen index value indicates that there is too much biologically active testosterone in the blood. This may indicate hormonal imbalance. Low-free androgen index indicates testosterone deficiency. Results should be further evaluated in consultation with the treating clinician.

The Free Androgen Index (FAI) is a ratio that estimates the amount of biologically active testosterone in the blood by dividing the total testosterone level by the sex hormone-binding globulin (SHBG) level and multiplying by 100.

The FAI test detects the level of biologically active testosterone in the blood, helping to identify conditions associated with abnormal androgen levels, such as hyperandrogenism, PCOS, and other androgen-related disorders.

The FAI test reports indicate the ratio of total testosterone to SHBG, providing an estimate of the free testosterone levels. High FAI values can indicate hyperandrogenism, while low values might suggest hypogonadism.

Yes, hormonal imbalances detected by the FAI test can be treated. Treatment options depend on the underlying condition and may include hormonal therapies, lifestyle changes, and medications to manage symptoms and restore hormonal balance.

The benefits of the FAI test include early diagnosis of hyperandrogenism and related conditions, monitoring the effectiveness of treatments for hormonal imbalances, and providing insights into cardiometabolic health, as FAI levels are linked to insulin resistance, dyslipidemia, and systemic inflammation.

Yes, women can undergo the FAI test, particularly when there is a suspicion of hyperandrogenism or conditions like PCOS. The test is more accurate for assessing free testosterone levels in women than in men.

The FAI test is a blood test and carries minimal risks associated with blood sampling, such as bruising, infection, or temporary discomfort at the puncture site.

The FAI test helps in diagnosing conditions such as PCOS, congenital adrenal hyperplasia, androgen-secreting tumors, Cushing syndrome, hyperandrogenism, and hypogonadism in certain contexts.

Yes, certain medications can affect the FAI test results. Hormonal contraceptives can elevate SHBG levels, while glucocorticoids can suppress SHBG production, thereby affecting the FAI. Other medications and chronic conditions can also impact SHBG and androgen levels.

No specific preparation, such as fasting, is typically required before taking the Free Androgen Index test. However, it is important to follow any instructions given by your healthcare provider.

Several factors can affect FAI test results, including the time of day, hormonal intake (e.g., contraceptives, glucocorticoids), obesity and insulin resistance, chronic conditions (e.g., HIV/AIDS, hepatitis C, liver disease), age, genetics, and ethnicity.

Free Androgen Index test results are usually available after 8 hours, although this can vary based on the healthcare provider and the time/day the sample is collected and processed.