Cortisol Test - Serum

The Cortisol 8.00 am test measures the concentration of cortisol in the blood at 8:00 am.

• Diagnosis of Adrenal Disorders:

1. Cushing's Syndrome: Elevated cortisol levels at 8:00 am may indicate Cushing's syndrome, a condition characterized by excessive cortisol production.
2. Addison's Disease: Low cortisol levels at 8:00 am may suggest Addison's disease, an adrenal insufficiency condition.

• Monitoring Cortisol Replacement Therapy: For individuals receiving cortisol replacement therapy, the test is used to monitor the effectiveness of treatment.
• Identification of Hormonal Imbalances: The test is part of a comprehensive hormonal evaluation, especially when hormonal imbalances are suspected. It aids in identifying disruptions in the endocrine system.
• Evaluation of Stress Response: Cortisol is often referred to as the "stress hormone." Measuring cortisol levels in the morning provides insight into the body's ability to mount a proper stress response.
• Risk Assessment for Associated Conditions: Elevated cortisol levels may be associated with an increased risk of conditions such as hypertension, diabetes, and cardiovascular disease. Monitoring cortisol levels can contribute to assessing overall health risks.

• If a person exhibits symptoms such as abdominal obesity, thin skin, easy bruising, and high blood pressure, a cortisol 8:00 am test may be recommended to investigate possible Cushing's syndrome.
• In cases where symptoms such as fatigue, weight loss, and low blood pressure suggest Addison's disease, the test may be used to assess cortisol levels.
• Individuals receiving cortisol replacement therapy due to adrenal insufficiency may undergo this test to ensure appropriate dosing and management.
• The test may be part of a broader hormonal evaluation, especially when hormonal imbalances are suspected.

Abnormal results may indicate various conditions, including Cushing's syndrome or Addison's disease. Elevated cortisol levels may suggest an overproduction (Cushing's), while low levels may indicate an underproduction (Addison's) of cortisol.

The test involves taking a blood sample at 8:00 am. A healthcare professional will insert a needle into a vein to collect the blood. The procedure is relatively quick and typically causes minimal discomfort.

No specific preparations are required. However, specific instructions from the healthcare provider should be followed. Inform the healthcare team about any medications or supplements you are taking, as certain drugs can affect cortisol levels.

Additional tests that may be ordered include:

• 24-Hour Urinary Free Cortisol Test: Measures the total amount of cortisol excreted in the urine over 24 hours.
• ACTH Stimulation Test: Evaluates the adrenal glands' response to adrenocorticotropic hormone (ACTH).

• Morning Cortisol Test
• AM Cortisol Test

Cortisol plays a crucial role in the body's response to stress and is involved in various physiological functions. When the body perceives a stressor, whether it's a physical threat or a psychological stressor, the hypothalamus (a region in the brain) releases corticotropin-releasing hormone (CRH). CRH signals the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH, in turn, stimulates the adrenal glands to produce and release cortisol into the bloodstream. The release of cortisol is part of the body's "fight or flight" response to stress. Cortisol increases the availability of glucose in the bloodstream, providing the body with a quick source of energy to respond to the stressor. Cortisol acts on various tissues and organs to prepare the body to cope with the stress. It increases heart rate, mobilizes energy stores, and suppresses non-essential functions like digestion and immune response.

• Chronic stress and elevated cortisol levels have been linked to abdominal obesity. Cortisol promotes the storage of fat in the abdominal area, contributing to weight gain.
• Elevated cortisol levels can contribute to insulin resistance, a key factor in the development of metabolic syndrome and type 2 diabetes.
• Chronic stress and dysregulated cortisol levels are associated with hypertension (high blood pressure), a significant risk factor for cardiovascular diseases.
• Prolonged exposure to high cortisol levels can suppress the immune system, making individuals more susceptible to infections and illnesses.
• Chronic stress or disruptions in daily routines can lead to altered cortisol patterns, contributing to sleep disturbances.
• Dysregulation of cortisol has been implicated in mental health disorders such as depression and anxiety.
• Chronic stress and altered cortisol levels can influence reproductive hormones, potentially contributing to menstrual irregularities and fertility issues.
• Some research suggests that chronic stress and elevated cortisol levels may contribute to accelerated aging processes at the cellular level.