Coeliac disease profile-1 Test

The Celiac disease profile measures the endomysial Antibody, tTg antibody levels in the blood.

• For diagnosing Coeliac disease, an autoimmune disorder of the small intestine.

People with the following symptoms:

• Recurrent symptoms of diarrhoea with or without blood, constipation, nausea, vomiting, bloating on consumption of gluten or gluten induced food items.
• Symptoms of gluten induced malabsorption, loss of bone density, infertility, neurological symptoms or even cancers.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

None.

Endomysial Antibody IgA

Presence of antibodies (Positive result) may be seen in gluten sensitive enteropathy (children: celiac disease, adult: non tropical sprue). Antibodies against endomysium and gliadin are rarely seen in healthy individuals and in other intestinal diseases.

tTG (Tissue Transglutaminase) IgA

tTG activity is increased (Positive Result) in the jejunal mucosa in Celiac disease/Gluten sensitive enteropathy, which is a chronic condition affecting genetically susceptible individuals.

Results should be correlated with the clinical features and with the other test results as well.

• Endomysial Antibody test
• tTG (Tissue Transglutaminase) Test
• IgA test.

Antibodies against endomysium of class IgA can be found in gluten sensitive enteropathy [in children and adults].

tTG is a calcium-dependent enzyme widely distributed in body fluids and tissues especially the gastrointestinal submucosa. The test is used for the detection of autoantibodies of IgA class directed against tissue transglutaminase (tTG) in human serum or plasma.