Carba R (Carbapenem Resistance )

Carba R (Carbapenem Resistance by PCR) enables the detection of genes associated with carbapenem resistance. These genes include IMP, VIM, NDM, KPC, and OXA 48. The presence of these genes indicates the potential for bacteria to resist treatment with carbapenem antibiotics, crucial for determining effective antibiotic therapy.

This test is done to:

• Confirm carbapenem resistance in bacterial infections
• Guide appropriate antibiotic therapy for effective treatment
• Prevent the spread of drug-resistant bacteria
• Assess the risk of treatment failure due to drug-resistant strains
• Aid infection control measures in healthcare settings

Doctors recommend this test for:

• Suspected or confirmed cases of carbapenem-resistant bacterial infections
• Patients not responding to initial antibiotic treatment
• Those with a history of recurrent infections
• Healthcare workers to monitor the spread of drug-resistant bacteria
• Individuals at high risk for healthcare-associated infections

An abnormal range could indicate the presence of IMP, VIM, NDM, KPC, or OXA 48 genes., and potential bacterial resistance to carbapenems. Discuss the results with your doctor for appropriate treatment adjustments.

During the test, expect:

• Collection of a specimen from infected sites
• Laboratory analysis using the PCR method to detect resistance genes
• Results usually being available after 6 hours for prompt treatment decisions

Before the test:

• No specific preparation is needed unless specified by your healthcare provider.
• Ensure samples are correctly labelled and transported to the laboratory promptly.
• Inform your doctor about any ongoing antibiotics.

Tests often ordered alongside include:

• Bacterial culture and sensitivity testing: Helps identify the infecting bacteria and their antibiotic susceptibility profiles
• Blood tests: To assess infection markers like white blood cell count and inflammatory markers
• Imaging studies: Such as X-rays or CT scans for infection localisation

Carbapenemase gene detection test or Carbapenemase resistance testing

Carbapenem Resistance is a condition where bacteria develop resistance to carbapenem antibiotics, crucial drugs used for severe infections when other antibiotics fail. Resistant strains pose challenges in treating infections and may lead to more extended hospital stays or even fatalities.