NextGen BRCA Somatic, FFPE tissue

This test measures specific genetic mutations in the BRCA genes. Mutations in these genes increase the risk of developing certain types of cancer, particularly breast and ovarian cancer.

• To identify mutations in the BRCA genes that may increase the risk of developing certain types of cancer

• To determine eligibility for targeted therapies, such as PARP inhibitor therapy

• To assess the response to treatment in patients receiving PARP inhibitor therapy

• To provide a personalised risk assessment for individuals with a family history of breast or ovarian cancer

This test is recommended for individuals who

•  have a personal or family history of breast or ovarian cancer,
•  have already been diagnosed with breast or ovarian cancer and want to determine if they have an inherited mutation,
• are considering or undergoing targeted therapies, such as PARP inhibitor therapy, or
• have a family member with a known BRCA mutation.

Abnormal results may indicate the presence of specific genetic mutations that increase the risk of developing certain types of cancer.

A sample of tissue containing the tumour, fixed in formalin and embedded in paraffin, will be required for testing. The test uses a method called Next-Generation Sequencing (NGS) to analyse the specific BRCA gene mutations.

• Provide your clinical history and any relevant histopathology reports.

• Follow any specific instructions given by your doctor regarding fasting or medication usage prior to the test.

• Inform your doctor if you have any specific requirements.

• BRCA1/2 germline testing: This test identifies inherited mutations in the BRCA genes.

• HER2 testing: This test determines whether a patient's cancer cells have an excess of HER2 protein, which helps guide treatment decisions.

• Hormone receptor testing: This test determines if cancer cells contain receptors for oestrogen or progesterone, aiding in treatment selection.

Next-Generation Sequencing (NGS) BRCA Somatic Test

Breast cancer is a disease that occurs when there is uncontrolled growth of abnormal cells in the breast tissue, often forming a lump or mass. Ovarian cancer refers to abnormal cell growth in the ovaries. Both cancers can be life-threatening if not detected and treated early.