BOH Profile Test - BOH (Bad Obstetric History) Profile-Maxi Karyotyping couple

BOH (Bad Obstetric History) Profile-Maxi includes the ANA, APA-IgG / IgM, ACAIgG / IgM, LAC, TSH, TORCH-13 tests. Apart from this the Karyotyping of Couple is also done.

The test is done to diagnose and detect causes for failed pregnancies, spontaneous abortions, neonatal deaths, stillborn etc. These may include:

• Thyroid dysfunction
• Infections, especially TORCH
• Anatomical factors
• Thrombophilia
• Coagulation Disorders
• Autoimmune disorders. 
• Genetic causes (diagnosed through Karyotyping, subsequent tests may be suggested if abnormality is detected)

• Couples experiencing consecutive spontaneous abortions.
• Couples having difficulty conceiving or experiencing multiple failed pregnancies.
• Women having difficulty in the current or previous pregnancy; like foetal growth retardation, early neonatal deaths, stillborn.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer. For couple karyotyping blood sample of both husband and wife is required.

No special precautions.

LAC test

Abnormal APTT levels and presence of Lupus anti-coagulant antibody may occur in cases of recurrent abortions. The results may be transient and persisting.

Cardiolipin AntibodyACL- IgG

Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and are associated with thrombotic states and can cause recurrent abortions and infertility.

TORCH-13

Presence of antibodies against the infections under the TORCH complex may indicate maternal infections which increases the risk of transmission to foetus and may lead to foetal abnormalities and abortion.

• ANA Test
• APA test
• ACA test
• LAC test
• TSH
• TORCH-13 test
• Couple Karyotyping test

: Presence of Anti-nuclear antibodies are associated with autoimmune diseases which can cause infertility and pregnancy loss.

Anti-Cardiolipin Aantibodies (ACA) are autoimmune in nature and are associated with thrombotic states and can cause recurrent abortions.

Lupus anticoagulants are antibodies detected that are associated with a thrombotic tendency and clinical states such as recurrent abortions. Their presence may be persistent or transiting.

This includes tests to detect infections or antibodies under the TORCH complex i.e. Toxoplasmosis, Rubella infections, Herpes Simplex and Cytomegalo Virus (CMV) infections. These infectious agents can cause abortion but usually are not seen as a cause of recurrent pregnancy failure. Testing both IgG and IgM antibodies can help in timing of infection acquisition.

Couple karyotyping is done in couples experiencing recurrent pregnancy loss and abortions to detect any gross structural anomalies, microdeletions, microduplications, single gene disorders that may be contributing to pregnancy loss.

Tests for thyroid hormones help in detecting any hormonal causes for recurrent pregnancy loss.