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Autoimmune Liver Disease Profile 1 Test
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Sample Type
Blood
Recommended for
Male, Female
Report
Within 1 Week
Blood test at Home
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Overview
Autoimmune Liver Disease Profile 1 /Autoimmune hepatitis 1 contains ANA, ASMA, LKM1, AMA which Facilitate early diagnosis of autoimmune hepatitis & Primary Biliary Cirrhosis
Autoimmune liver disease refers to a group of disorders in which the immune system mistakenly attacks the liver. This results in inflammation and damage to the liver cells, leading to various degrees of liver injury. There are several types of autoimmune liver disease, the most common types are:
- Autoimmune hepatitis (AIH): It is characterized by inflammation and destruction of liver cells, resulting in cirrhosis, jaundice, fatigue, abdominal pain and itchy skin.
- Primary biliary cholangitis (PBC): it is a chronic disease characterized by inflammation and damage of the small bile ducts within the liver. This results in the obstruction of bile flow and eventually leads to cirrhosis, jaundice and itching.
- Primary sclerosing cholangitis (PSC): It is characterized by inflammation and scarring of the bile ducts, both inside and outside the liver, leading to bile duct obstruction, which can result in cirrhosis, jaundice, and itching.
The Autoimmune Liver Disease Profile 1 Test is a comprehensive blood test designed to aid in the diagnosis and monitoring of autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis. This specialised profile detects the presence of specific autoantibodies associated with these conditions, providing valuable insights into the patient's liver health and immune system function.
By identifying and measuring the levels of these autoantibodies, the Autoimmune Liver Disease Profile 1 Test helps doctors distinguish between various autoimmune liver disorders and determine the most appropriate course of treatment. This test is particularly useful for patients presenting with symptoms such as abdominal pain, jaundice, fatigue, or those with abnormal liver function tests or features of other autoimmune disorders.
Written by: Supriya Kulkarni, Lead-Content & Training
Reasons for Undergoing the Autoimmune Liver Disease Profile 1 Test
There are several reasons why a doctor may recommend the Autoimmune Liver Disease Profile 1 Test, including:
- Abnormal liver function tests, such as elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels
- Presence of symptoms associated with liver disease, such as abdominal pain, jaundice, itchy skin, and fatigue
- Hypergammaglobulinemia or features of other autoimmune disorders, which may indicate an underlying autoimmune liver condition
- To differentiate autoimmune hepatitis from other causes of liver injury
List of Parameters Considered During the Autoimmune Liver Disease Profile 1 Test
The Autoimmune Liver Disease Profile 1 Test measures several key autoantibodies to help diagnose and differentiate between various autoimmune liver diseases:
- Antinuclear Antibodies (ANA): Found in approximately 80% of patients with type 1 autoimmune hepatitis (AIH-1), ANA positivity indicates the presence of an autoimmune process, particularly in AIH-1.
- Anti-Smooth Muscle Antibodies (ASMA): Also known as anti-actin antibodies, ASMA are present in about 63% of patients with AIH-1 and serve as another marker for this condition.
- Liver-Kidney Microsomal Antibody Type 1 (LKM-1): A hallmark of type 2 autoimmune hepatitis (AIH-2), LKM-1 antibodies are often found in patients who are ANA and ASMA negative but still suspected to have AIH.
- Anti-Mitochondrial Antibodies (AMA): Typically associated with primary biliary cirrhosis rather than autoimmune hepatitis, AMA positivity indicates a different autoimmune liver condition.
Autoimmune Liver Disease Profile 1 Test Preparation
Preparing for the Autoimmune Liver Disease Profile 1 Test is a straightforward process:
- Blood Sample Collection: A phlebotomist will place a tourniquet (elastic band) tightly on the upper arm and ask the patient to make a fist, which helps build up blood in the veins. The skin will be disinfected before the needle is inserted to minimise the risk of infection.
- Sample Handling: The blood sample is collected in a vacutainer and separated from cells as soon as possible or within 2 hours of collection. The serum is then transferred to a transport tube and refrigerated.
Autoimmune Liver Disease Profile 1 Test Results & Interpretation
TThe results of the Autoimmune Liver Disease Profile 1 Test are interpreted based on the presence and levels of the autoantibodies:
- ANA: Positive at titres of 1:40 or higher, with higher titres (e.g., 1:80 or greater) being more indicative of autoimmune hepatitis type 1.
- ASMA: Positive at levels above 20 units (weak positive: 20-30 units, strong positive: 31 units or greater).
- LKM-1: Positive at levels of 25 units or greater.
- AMA: Positive at levels of 25 units or greater.
A positive result for any of these antibodies suggests the presence of an autoimmune liver disease.
Home Collection for Autoimmune Liver Disease Profile 1 Test Near You
Metropolis Healthcare offers a convenient home sample collection service for the Autoimmune Liver Disease Profile 1 Test, ensuring patient comfort and safety without compromising on the quality of the test. A trained phlebotomist will visit the patient's home to collect the blood sample, maintaining high standards of sample handling and testing accuracy. This service ensures timely and reliable results, empowering patients to take proactive steps in managing their liver health. By making healthcare more accessible through home collection, Metropolis Healthcare demonstrates its commitment to providing quality diagnostic solutions conveniently at the patient's doorstep.
Autoimmune Liver Disease Profile 1 Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Autoimmune Liver Disease Profile 1 Test with a clear pricing structure.
The Autoimmune Liver Disease Profile 1 Test Price in Mumbai is ₹ 6,100 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
To help diagnose autoimmune hepatitis and distinguish it from other causes of liver injury
This test is done for patients suspected of suffering from autoimmune liver disease
ANA antibodies are Present in 80% of type 1 AIH patients whereas ASMA antibodies are Present in 63% of type 1 AIH , LKM1is a Hallmark of type 2 AIH, AMA is present in primary biliary cirrhosis
- An autoimmune liver disease profile-1 is typically ordered when an autoimmune liver disease, such as autoimmune hepatitis or primary biliary cirrhosis is suspected.
- The autoimmune liver disease profile-1 is a group of blood tests that can help diagnose and monitor the progression of these conditions.
- The autoimmune liver disease profile-1 is used to detect the presence of specific antibodies that are associated with autoimmune liver disease.
You should get the Autoimmune Liver Disease Profile -1 done if you observe the following symptoms:
- Abdominal pain
- Jaundice
- Itchy skin
- Fatigue
The Autoimmune Liver Disease Profile -1 measures the autoantibodies antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA; also called anti-actin antibody), liver-kidney microsomal antibody type 1 (LKM-1), and anti-mitochondrial antibody (AMA).
This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.
ASMA, AMA, LKM1, and ANA are all antibodies that can be found in the blood of individuals with autoimmune liver disease.
- A positive test for anti-smooth muscle antibodies (ASMA) suggests an autoimmune liver disease such as primary biliary cirrhosis (PBC).
- Anti-mitochondrial antibodies (AMA) are specific to primary biliary cirrhosis (PBC), a form of autoimmune liver disease.
- Liver-kidney microsomal antibodies (LKM) are antibodies directed against enzymes found in the liver and kidney. A positive LKM1 test suggests autoimmune hepatitis (AIH)
- Anti-nuclear antibody (ANA) is a general marker for autoimmune disorders, as ANA can be found in a variety of autoimmune diseases including autoimmune liver disease. However, a positive ANA test alone is not specific for autoimmune liver disease, as ANA is found in many different autoimmune diseases.
Associated Tests:
- Autoimmune Liver Disease Profile-3
- Autoimmune Liver Disease Profile-4
The Autoimmune Liver Disease Profile 1 Test is a group of blood tests that help diagnose and monitor autoimmune liver diseases, such as autoimmune hepatitis and primary biliary cirrhosis, by detecting the presence of specific autoantibodies.
Home sample collection is available for the Autoimmune Liver Disease Profile 1 test at select labs, including Metropolis.
Normal levels are as follows: ANA-negative at titers below 1:80; ASMA-negative at levels below 20 units; LKM-1-negative at levels below 20 units; AMA-negative at levels below 20 units.
The Autoimmune Liver Disease Profile 1 Test is used to diagnose and differentiate autoimmune liver diseases such as autoimmune hepatitis and primary biliary cirrhosis from other liver conditions.
Testing frequency depends on the clinical context and the need for monitoring disease progression or response to treatment. It is typically done when symptoms suggest autoimmune liver disease or during follow-up for diagnosed patients.
There is no specific time requirement for the Autoimmune Liver Disease Profile 1 Test, and it can be done at any time as per the doctor's advice.
No, fasting is not required for the Autoimmune Liver Disease Profile 1 Test.
Ensure the blood sample is collected correctly and the specimen is handled and stored properly to avoid contamination or degradation.
The parameters included in the Autoimmune Liver Disease Profile 1 Test are antinuclear antibodies (ANA), anti-smooth muscle antibodies (ASMA), liver-kidney microsomal antibody type 1 (LKM-1), and anti-mitochondrial antibodies (AMA).
The Autoimmune Liver Disease Profile 1 Test should be done when symptoms such as abdominal pain, jaundice, itchy skin, and fatigue suggest autoimmune liver disease.
The blood sample collection process for the Autoimmune Liver Disease Profile 1 Test typically takes a few minutes.
Reports for the Autoimmune Liver Disease Profile 1 Test are usually available within 24 to 48 days depending on the day/time when the sample was collected and processed.
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We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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