Array Feto

Provide in depth analysis and root causes of multiple recurrent abortions, pregnancy losses
This technique is not limited by tissue culture failure which affects traditional techniques like karyotyping

Array feto test is done for the following reasons:

• Assess the causes of numerous recurring abortions and miscarriages by examining the fetal tissue of aborted pregnancies and stillbirths.
• Detection of chromosomal aneuploidy, large chromosomal change, sub-microscopic abnormalities, and copy number variation (CNV).
• Detect aneuploidies like Trisomy's, large deletions & copy number variants.

CGH detects chromosomal aneuploidy, large chromosomal change, sub microscopic abnormalities, copy number variation (CNV)

Your doctor will guide you on sample collection.

• For gestation up to 12 weeks: 50-100mg placental villi (fetal side) in 20ml normal saline with 2-3 drops of gentamycin in a sterile container.
• For gestation up to 12-18 weeks: a) 50-100mg placental villi (fetal side) in 20ml normal saline with 2-3 drops of gentamycin in a sterile container. b) and or fetal Muscle tissue preferably medial aspect of thigh muscle or a fetal toe in sterile container.
• For gestation up to IUFD >20 weeks: fetal Muscle tissue preferably medial aspect of thigh muscle or a fetal toe in sterile container. if possible in 20ml normal saline with 2-3 drops of gentamycin.

Samples should be refrigerated at 2-8 C but not frozen. Maternal blood sample in EDTA is mandatory

CGH can detect aneuploidies like Trisomy's, large deletions & copy number variants. Patients must consult their doctor/ genetic counsellor to understand the significance of the reported findings.
This technique will not detect balanced chromosome rearrangements (which do not result in deletion or duplication of genetic material) and low level mosaicism

Large deletions, copy number variations, and trisomies are among the aneuploidies that may be identified. To comprehend the relevance of the provided data, patients must speak with their doctor or genetic counsellor. This method cannot identify low-level mosaicism and balanced chromosomal rearrangements, which do not result in the deletion or replication of genetic material. 

Array feto test is indicated in:

• Advanced maternal age
• Abnormal maternal serum screen
• Family members showing familial chromosomal abnormalities
• Fetus with a known chromosomal abnormality
• Cell-free DNA (cf-DNA) in the maternal blood on non-invasive prenatal testing (NIPT)
• Fetal abnormality on ultrasound
• Previous multiple abortions and miscarriages

The Array Feto test is done on the chorionic villus, the amniotic fluid, the products of conception after an abortion or a miscarriage, the foetal tissue after a stillbirth, and the mother's blood to look for chromosomal abnormalities. Fetal abnormalities on ultrasound and abnormal maternal screening tests require Array feto test to check for chromosomal abnormalities.

Please follow the sample collection guidelines, as prescribed by your doctor

Depending upon the requirement, a maternal cell contamination screening test, chromosome analysis of amniotic fluid or chorionic villus, and alpha-fetoprotein with reflex to acetylcholinesterase, and fetal haemoglobin, are the other tests that may be recommended.

1. Chromosomal Array CGH
2. Oligonucleotide Array
3. Oligo Array
4. Molecular Karyotype
5. Constitutional Array
6. Prenatal Diagnosis
7. aCGH
8. Array CGH (Array Comparative Genomic Hybridization)