Anaemia Profile-Haemolytic Type

To detect hemolytic anemia.

This test is for individulas to evaluate hemolytic anemia.

This profile detects hemolytic type of anemia. This profile includes CBC, Reticulocyte Count, G6PD, Osmotic Fragility, Haptoglobulin, Abnormal Hb Studies, LDH, COOMBS Direct,Bilirubin.

• Anaemia Profile- Haemolytic Type Test is done to diagnose hemolytic anaemia and to identify its causes.
• Anaemia Profile- Haemolytic Type is done in people who show signs and symptoms of hemolytic anaemia, who do not respond to the treatment for anaemia, in patients with family history of a hereditary anaemia, in pregnant women, in patients with chronic diseases and chronic infections.

You should get the hemolytic anemia test done if you observe the following symptoms:

• Fatigue
• Weakness
• Tiredness
• Irritability
• Headache
• Shortness of breath

• Patient Preparation: 12-14 hrs fasting required 

   

  Total Tests Included: 9 (CBC (27 parameters), Reticulocyte Count, G6PD, Osmotic Fragility, Haptoglobulin, Abnormal Hb Studies, LDH, COOMBS Direct, Bilirubin)

   

  TAT: From DOS 

Anaemia Profile- Haemolytic Type Profile includes the following group and individual test:

• CBC tests for all Blood cells like RBC, WBC and Platelets, their count and morphology along with Hemoglobin level (Hb), RBC indices (MCV, MCH, MCHC, RDW) & PDW.
• Reticulocyte count is useful in monitoring treatment in anaemic patients and also to know the bone marrow activity. CRP, TSH and Creatinine are essential to diagnose anaemias due to Chronic Diseases and Infections.
• LDH is found in red blood cells, and hemolysis releases it into the bloodstream.
• Bilirubin, a by-product of haemoglobin breakdown, rises as haemoglobin is released. In hemolysis, indirect hyperbilirubinemia is frequently observed.
• Haemolytic Anaemias are diagnosed by tests like Haptoglobin, Osmotic Fragility, Direct Coombs Test, G6PD and abnormal hemoglobin studies (for hemoglobinopathies).

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

From IT masters

As per WHO, women with Hb < 12mg/dL & men with Hb <13mg/dL are considered anaemic.

• In hemolytic anaemia, Hb, serum Iron, ferritin levels, transferrin saturation are low and TIBC level is high.
• In anaemia of chronic disease Hb, serum Iron, transferrin saturation, TIBC are low with high ferritin.
• In hemolytic anemia, bilirubin and LDH are elevated.
• Investigations like G6PD, Haptoglobin, Osmotic Fragility, DCT are abnormal in Haemolytic Anaemia.
• Abnormal Hb studies can detect Sickle cell & Thalassemia.
• CRP when high indicates Infection and Inflammation.
• Creatinine if increased indicates abnormality in kidney function.