17p Deletion by FISH, p53 (MM, CLL)

This test primarily identifies deletions in chromosome 17 and evaluates the presence of the p53 gene. These genetic alterations are crucial in predicting the progression and potential outcomes of conditions such as CLL and MM.

• Assessing prognosis in Chronic Lymphocytic Leukaemia and Multiple Myeloma
• Monitoring disease progression or response to treatment
• Guiding treatment decisions based on genetic markers

Doctors recommend this test for:

• Diagnosis or monitoring of CLL or MM
• Patients with existing diagnoses needing treatment guidance
• Those requiring prognostic information for tailored care

Abnormal results could indicate a poor prognosis in CLL or MM. It could also indicate an aggressive disease requiring specific treatment approaches. Discuss the results with your doctor for comprehensive guidance.

When undergoing this test:

• A blood sample will be collected using a Na-heparin vacutainer.
• Sample preservation instructions are similar to those for other blood tests.
• Analysis will be done using the fluorescence in-situ hybridization method.

Before the test:

• No specific dietary or lifestyle restrictions are needed.
• Inform your doctor about the medications you take.
• Follow guidelines regarding fasting or sample collection as instructed by your healthcare provider.

Other tests that may accompany this include:

• Immunophenotyping: Identifies cell markers to classify blood cancers precisely.
• Flow Cytometry: Assesses cell properties to aid in diagnosing various diseases.
• Bone Marrow Aspiration and Biopsy: Direct examination for blood disorders in bone marrow.

FISH Genetic Testing for CLL/MM or Chromosomal Deletion Testing for Leukaemia

Chronic lymphocytic leukaemia involves the overproduction of abnormal lymphocytes, while multiple myeloma affects plasma cells in the bone marrow. Both are types of blood cancer necessitating specialised management based on genetic markers like those evaluated in this test.