17p Deletion by FISH, p53 (MM, CLL)

This test primarily identifies deletions in chromosome 17 and evaluates the presence of the p53 gene. These genetic alterations are crucial in predicting the progression and potential outcomes of conditions such as CLL and MM.

• Assessing prognosis in Chronic Lymphocytic Leukaemia and Multiple Myeloma
• Monitoring disease progression or response to treatment
• Guiding treatment decisions based on genetic markers

Doctors recommend this test for:

• Diagnosis or monitoring of CLL or MM
• Patients with existing diagnoses needing treatment guidance
• Those requiring prognostic information for tailored care

Abnormal results could indicate a poor prognosis in CLL or MM. It could also indicate an aggressive disease requiring specific treatment approaches. Discuss the results with your doctor for comprehensive guidance.

When undergoing this test:

• A blood sample will be collected using a Na-heparin vacutainer.
• Sample preservation instructions are similar to those for other blood tests.
• Analysis will be done using the fluorescence in-situ hybridization method.

Before the test:

• No specific dietary or lifestyle restrictions are needed.
• Inform your doctor about the medications you take.
• Follow guidelines regarding fasting or sample collection as instructed by your healthcare provider.

Other tests that may accompany this include:

• Immunophenotyping: Identifies cell markers to classify blood cancers precisely.
• Flow Cytometry: Assesses cell properties to aid in diagnosing various diseases.
• Bone Marrow Aspiration and Biopsy: Direct examination for blood disorders in bone marrow.

FISH Genetic Testing for CLL/MM or Chromosomal Deletion Testing for Leukaemia

Chronic lymphocytic leukaemia involves the overproduction of abnormal lymphocytes, while multiple myeloma affects plasma cells in the bone marrow. Both are types of blood cancer necessitating specialised management based on genetic markers like those evaluated in this test.

The FISH 17p Deletion test is a diagnostic technique that uses fluorescent probes to detect the deletion of the short arm of chromosome 17, which includes the important TP53 tumour suppressor gene. This test is crucial for evaluating patients with certain blood cancers.

Home sample collection is available for FISH 17p Deletion test. A trained phlebotomist can visit your home to collect the required blood or bone marrow sample, ensuring comfort, safety, and reliable results.

In a normal FISH 17p deletion test result, two fluorescent signals per cell are observed for the TP53 gene, indicating no deletion. Any significant percentage of cells with only one or no signal suggests an abnormal result and the presence of the deletion.

The FISH 17p deletion test is primarily used to diagnose and manage haematologic malignancies such as Chronic Lymphocytic Leukaemia (CLL), Acute Myeloid Leukaemia (AML), Myelodysplastic Syndromes (MDS), and plasma cell neoplasms. It helps assess prognosis and guide treatment decisions.

The frequency of the FISH 17p deletion test depends on your clinical situation. Generally, the test is performed at diagnosis and at key points during treatment to monitor disease progression and detect any new chromosomal abnormalities.

The timing for undergoing FISH 17p deletion test depends on the healthcare provider's recommendations. Typically, the test is done at diagnosis, before starting treatment, and at follow-up intervals determined by your doctor based on your specific condition.

No, fasting is not required for FISH 17p Deletion test. The test is performed on a bone marrow aspirate or blood sample, and dietary restrictions are not necessary.

The main precaution for FISH 17p deletion test is to ensure that the specimen is collected and handled correctly to avoid contamination and maintain cell viability. Follow the specific instructions provided by the laboratory for specimen collection and transport.

The primary parameter measured in FISH 17p deletion test is the presence or absence of the TP53 gene on chromosome 17p, indicated by the number of fluorescent signals observed per cell. The percentage of cells with the deletion is also quantified.

The FISH 17p deletion test should be done at diagnosis, before treatment initiation, and at subsequent points during treatment as clinically indicated by your healthcare provider. This helps guide treatment decisions and monitor disease progression.

The actual FISH 17p deletion test procedure and analysis take several days. However, as a patient, you will only be required to provide a bone marrow or blood sample, which takes a relatively short time.

The turnaround time for the FISH 17p deletion test results may vary depending on the lab. Typically, results are available within a week based on the day/time when the sample was collected and processed. However, consult with your healthcare provider or the specific lab for more precise timelines.