17-Hydroxyprogesterone/ 17-OH Progesterone Test

This test measures the concentration of 17-hydroxy-progesterone hormone in the serum.

• The test is typically performed to diagnose and monitor adrenal gland disorders, especially congenital adrenal hyperplasia (CAH)
• It helps assess the production of hormones, including cortisol, in the adrenal glands.
• It helps in monitoring cortisol replacement therapy
• It helps in evaluating infertility
• It is useful in evaluating adrenal and ovarian neoplasm

• This test is recommended when there is a suspicion of adrenal gland dysfunction or CAH.
• It is often ordered for individuals, including newborns, who exhibit symptoms or have a family history of CAH.

A positive 17-Hydroxy-Progesterone (17-OHP) test result doesn't necessarily mean you have a definite condition. However, it does indicate the need for further investigation. 

• In Newborns: A positive test in a newborn raises the possibility of Congenital Adrenal Hyperplasia (CAH). More specific tests are needed to confirm CAH diagnosis.
• In Adults: In adults, a positive result could suggest:
  • Untreated or poorly controlled CAH.
  • A less common possibility of infertility in men.
  • In rare cases, an adrenal or ovarian tumor (other tests are usually needed for confirmation).

The test involves a blood draw, where a healthcare professional collects a serum sample from a vein, typically in the arm. The procedure is minimally invasive and relatively quick.

There are no specific preparations required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status. Adhering to the healthcare provider's guidelines is essential for accurate test results.

Additional tests that may be ordered alongside the 17-Hydroxy-Progesterone test include hormonal assays to assess cortisol and other adrenal hormones.

• Cortisol Testing: Testing cortisol levels can provide additional information about adrenal function and help differentiate between various adrenal disorders. 
• ACTH Stimulation Test: This test involves injecting synthetic adrenocorticotropic hormone (ACTH) and measuring cortisol levels in response. It helps determine the cause of adrenal insufficiency or Cushing's syndrome. 
• Dexamethasone Suppression Test: This test involves administering dexamethasone, a synthetic corticosteroid, and measuring cortisol levels to assess adrenal function and diagnose conditions like Cushing's syndrome.
•  Aldosterone and Renin Testing: They can help diagnose disorders like primary aldosteronism or secondary aldosteronism.

17-OHP Test